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Suggest people not to adjust the dose of acetaminophen and codeine phosphate tablets with out consulting a health practitioner or other healthcare Experienced.

Two-yr carcinogenicity reports are conducted in F344/N rats and B6C3F1 mice. There was no evidence of carcinogenicity in male and female rats, respectively, at dietary doses around 70 and eighty mg/kg/day of codeine sulfate (roughly 2 periods the most recommended day-to-day dose of 360 mg/working day for adults on a mg/m2 foundation) for two several years.

Nursing Mothers At the least a person Loss of life was described inside a nursing infant who was subjected to substantial amounts of morphine in breast milk because the mother was an extremely-swift metabolizer of codeine. Breastfeeding is not advised through procedure with acetaminophen and codeine phosphate tablets.

In research performed through the Nationwide Toxicology System, fertility assessments with acetaminophen have been done in Swiss CD-one mice by means of a constant breeding examine. There were no effects on fertility parameters in mice consuming nearly one.seven moments the MHDD of acetaminophen, determined by a overall body surface area comparison. Although there was no impact on sperm motility or sperm density from the epididymis, there was a significant boost in The share of abnormal sperm in mice consuming one.

Sufferers ought to be knowledgeable with regard to the indicators of great skin reactions, and use with the drug should be discontinued at the main look of skin rash or any other signal of hypersensitivity.

Opioids cross the placenta and may make respiratory depression and psycho-physiologic effects in neonates. An opioid antagonist, which include naloxone, has to be accessible for reversal of opioid-induced respiratory despair inside the neonate. Acetaminophen and codeine phosphate tablets are not advisable for use in pregnant women in the course of or immediately just before labor, when other analgesic methods are more ideal.

Notify individuals that use of opioids for an extended period of time may well result in decreased fertility. It is not regarded no matter whether these effects on fertility are reversible (see ADVERSE REACTIONS).

Parenteral drug abuse is often associated with transmission of infectious health conditions for instance hepatitis and HIV.

Use the lowest effective dosage to the shortest duration of your time consistent with specific patient procedure targets [see Warnings]. As the threat of overdose improves as opioid doses boost, reserve titration to bigger doses of acetaminophen and codeine phosphate tablets for individuals in whom lessen doses are insufficiently powerful As well as in whom the anticipated great things about utilizing an increased dose opioid clearly outweigh the considerable dangers.

Discomfort remedies operate ideal if they are applied as the initial signs of soreness happen. For those who wait around right until the soreness has worsened, the medication may not get the job done too.

We anticipate reposting the photographs after we are equipped click here discover and filter out pictures that don't match the knowledge provided during the drug labels. NDC Codes

Use with caution; start with reduce doses or with extended dosing intervals and titrate slowly although thoroughly checking for Negative effects.

Advise sufferers and caregivers that when check here medicines are no more desired, they should be disposed of immediately. get more info Notify people that medicine get-back again possibilities are the popular solution to safely get rid of most forms of unneeded medicines.

Other get more infohere pain relievers (such as naproxen, ibuprofen) might also be prescribed with this medication. Check with your health care provider or pharmacist about applying this product safely with other drugs.